patho-tb test for the rapid diagnosis of pulmonary tuberculosis

نویسندگان

roya alavi-naini associate professor

malihe metanat research center for infectious diseases and tropical medicine, zahedan university of medical sciences, boo-ali hospital, zahedan, iran

ebrahim alijani research center for infectious diseases and tropical medicine, zahedan university of medical sciences, boo-ali hospital, zahedan, iran

hassan mozaffar research center for infectious diseases and tropical medicine, zahedan university of medical sciences, boo-ali hospital, zahedan, iran

چکیده

background : despite recent technologic improvements in identifying mycobacterium tuberculosis, we are still facing problems in rapid diagnosis of tuberculosis. the objective of this study is to determine the diagnostic value of a new rapid screening test (patho-tb™) for diagnosis of pulmonary tuberculosis. methods : between september 2006 to august 2007, 178 patients were enrolled in the study who were finally classified into two groups; a group of documented pulmonary tuberculosis (n = 67) and a group of non-tuberculous pulmonary infection (n = 111). patho-tb™ test, ziehl-neelsen staining and culture were done on all specimens. results : of all, 43 patients with pulmonary tuberculosis were sputum smear positive for acid fast bacilli and the rest were smear negative. mean age of the patients was 59.8 ± 16.1 years and 44% of them were men. the results of patho- tb™ test were positive in 40 of smear positive and 20 of smear negative tuberculous patients and 33 cases of nontuberculous control group. the sensitivity, specificity, positive and negative predictive values and accuracy of patho- tb™ test were estimated 89.5%, 70.2%, 64.5%, 91.7% and 77.5%, respectively. conclusions : according to the present study it would be suggested that patho-tb™ test could be a rapid and inexpensive method for diagnosis of pulmonary tuberculosis, given by its high sensitivity and negative predictive value. concerning the high number of false positive results, using a confirmatory diagnostic procedure is mandatory. keywords : pulmonary tuberculosis, rapid diagnosis, mycobacterium tuberculosis antigens, iran

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عنوان ژورنال:
journal of research in medical sciences

جلد ۱۴، شماره ۵، صفحات ۳۰۱-۰

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